Fumio will give talks at Singapore Temasek Lifesciences Lab (Sep 28, 2021) and at the iC Cubix3 symposium "The 4th Australia-Belgium-Japan symposium on excitonics and cellular communications" (Oct 21-22, 2021).
A new study "Crosstalk between myosin II and formin functions in the regulation of force generation and actomyosin dynamics in stress fibers" by Yukako and her collaborators was published in Cells & Development.
A review article "Fluid Flow Dynamics in Cellular Patterning" by Fumio and his collaborator, Kenji Kimura of Kwansei Gakuin Univ., was published in Seminars in Cell and Developmental Biology. Thanks Kenji for his contribution.
Our group is interested in understanding the mechanical processes regulating: 1) The initiation of cell polarization and 2) The spatial patterning of cellular asymmetry. The simple model nematode system Caenorhabditis elegans provides a unique opportunity to explore such topics, as the embryos undergo de novo polarization with stereotypical spatio-temporal kinetics. We are also using cultured mammalian cells to investigate conserved cell polarity circuits. By using a multi-disciplinary approach, combining genetics, biochemistry, and modern imaging technology, our group aims to understand: 1. The nature of the cue(s) that initiate cell polarization 2. The mechanics of spatial patterning of cellular asymmetry 3. The role of polarity kinases in the germ-soma dichotomy 4. The mechanisms underlying tissue homeostasis
In order to delve into the mysteries in living systems, we develop new types of confocal fluorescence microscopies and image behaviours of molecules, cells, and tissues in living animals. See the beauty in microtubules, actin filaments, and regulators of cellular asymmetry in live cells.
We acknowledge the following foundations and organization, which support our research program in Singapore and Japan.