Pasapera AM, Heissler SM, Eto M, Nishimura Y, Fischer RS, Thiam HR, Waterman CM. (2022) MARK2 regulates directed cell migration through modulation of myosin II contractility and focal adhesion organization. Current Biology. DOI:https://doi.org/10.1016/j.cub.2022.04.088
2021
Tsutsui K, Kim HS, Yoshikata C, Kimura K, Kubota Y, Shibata Y, Tian C, Liu J, Nishiwaki K. (2021) Repulsive guidance molecule acts in axon branching in Caenorhabditis elegans. Scientific Reports. 16;11(1):22370. Nishimura Y, Shi S. Li Q, Bershadsky AD, Viasnoff V. (2021) Closstalk between myosin II and formin functions in the regulation of force generation and actomyosin dynamics in stress fibers. Cells & Development. https://doi.org/10.1016/j.cdev.2021.203736
Kimura K, Motegi F. (2021) Fluid flow dynamics in cellular patterning. Seminars in Cell and Developmental Biology. http://doi.org/10.1016/j.semcdb.2021.07.004
Lim YW, Wen FL, Shankar P, Shibata T, Motegi F. (2021) A balance between antagonizing PAR proteins specifies the pattern of asymmetric and symmetric cell divisions in C. elegans embryogenesis. Cell Reports. 36, 109326.
Nishimura Y, Shi S, Zhang F, Liu R, Takagi Y, Bershadsky AD, Viasnoff V, and Sellers JR. (2021) The Forming Inhibitor, SMIFH2, Inhibits Members of the Myosin Superfamily. J Cell Sci, 134, jcs253708.
Gan WJ, and Motegi F. (2021) Mechanochemical Control of Symmetry Breaking in the Caenorhabditis elegant Zygote. Front Cell Dev Biol 8:619869.
2020
Kimura K and Kimura A. (2020) Cytoplasmic streaming drifts the polarity cue and enables posteriorization of the Caenorhabditis elegans zygote at the side opposite of sperm entry. Molecular Biology of the Cell. 31(16) 1765-1773. Motegi F, Plachta N, Viasnoff V. (2020) Novel approaches to link apico-basal polarity to cell fate specification. Current Opinion in Cell Biology 62: 78-85.
D. Thumkeo, Y. Katsura, Y. Nishimura, P. Kanchanawong, K. Tohyama, T. Ishizaki, S. Kitajima, C. Takahashi, T. Hirata, N. Watanabe, M. F. Krummel, S. Narumiya. (2020) mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse. Science Advances, vol. 6, no.1, eaay2432
2019
Zhao P, Teng X, Tantirimudalige SN, Nishikawa M, Wohland T, Toyama Y, Motegi F. (2019) Aurora-A breaks symmetry in contractile actomyosin networks independently of its role in centrosome maturation. Developmental Cell 48: 631-645.
Rafiq NM*, Nishimura Y*, Plotnikov SV, Thiagarajan V, Zhang Z, Natarajan M, Shi S, Viasnoff V, Jones GE, Kanchanawong P, Bershadsky AD. (*Co-first authors) (2019) A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions. Nature Materials, 18: 638-649
2018
Ramanujam R*, Han Z*, Zhang Z, Kanchanawong F, Motegi F (*Co-first authors). (2018) Establishment of the PAR-1 cortical gradient by the aPKC-PRBH circuit. Nature Chemical Biology 14: 917-927. DOI: 10.1038/s41589-018-0117-1
2017
Kimura K, Mamane A, Sasaki T, Sato K, Takagi J, Niwayama R, Hufnagel L, Shimamoto Y, Joanny JF, Uchida S, and Kimura A. (2017) Endoplasmic reticulum-mediated microtubule alignment governs cytoplasmic streaming. Nature Cell Biology. 19(4):399-406. J, Kim T, Osorio D, Motegi F, Carvalho AX, Oegema K, and Zanin E. (2017) TPXL-1 Activates Aurora A to Clear Contractile Ring Components from the Polar Cortex during Cytokinesis. Journal of Cell Biology, The DOI: 10.1083/jc.
Zhen Zhang*, Yen Wei Lim*, Peng Zhao, Pakorn Kanchanawong, and Fumio Motegi (*Co-first authors). (2017) ImaEdge: a platform for the quantitative analysis of cortical proteins spatiotemporal dynamics during cell polarization. Journal of Cell Science 130: 4200-4212. doi: 10.1242/jcs.206870.
Shyi-Chyi Wang, Tricia Yu Feng Low, Yukako Nishimura, Laurent Gole, Weimiao Yu, Fumio Motegi. (2017) Cortical forces and CDC-42 control clustering of PAR proteins for C. elegans embryonic polarization. Nature Cell Biology 19: 988-995. http://dx.doi.org/10.1038/ncb3577.
Ravikrishna Ramanujam, Tricia Yu Feng Low, Yen Wei Lim, Fumio Motegi. (2017) Forceful patterning in mouse preimplantation embryos. Seminars in Cell & Developmental Biology 71: 129-136. doi: 10.1016/j.semcdb.2017.05.011.
Zhen Zhang*, Yukako Nishimura*, Pakorn Kanchanawong. (*Co-first authors) (2017) Extracting Microtubule Networks from Superresolution Single-Molecule Localization Microscopy Data. Molecular Biology of the Cell, 28(2): 333-325
2016
Arata Y, Hiroshima M, Pack CG, Ramanujam R, Motegi F, Nakazato K, Shindo Y, Wiseman PW, Sawa H, Kobayashi TJ, Brandão HB, Shibata T, Sako Y. (2016) Cortical Polarity of the RING Protein PAR-2 Is Maintained by Exchange Rate Kinetics at the Cortical-Cytoplasmic Boundary. Cell Reports 16(8): 2156-2168.
2013
Motegi F and Seydoux G. (2013) The PAR network: redundancy and robustness in a symmetry-breaking system. Philosophical Transactions of the Royal Society B, invited review 368: 20130010.
2012
Hayashi h, Kimura K and Kimura A. (2012) Localized accumulation of tubulin during semi-open mitosis in the Caenorhabditis elegans embryo. Molecular Biology of the Cell. 23(9): 1688-99.
Kimura K and Kimura A. (2012) Rab6 is required for the exocytosis of cortical granules and the recruitment of separase to the granules during the oocyte-to-embryo transition in Caenorhabditis elegans. Journal of Cell Science. 125(23): 5897-905. Yukako Nishimura, Kathryn Applegate, Michael W. Davidson, Gaudenz Danuser, and Clare M. Waterman. (2012) Automated Screening of Microtubule Growth Dynamics Identifies MARK2 as a Regulator of Leading Edge Microtubules Downstream of Rac1 in Migrating Cells. PLoS One, 7 (7): e41413.
2011
Ihara S, Hagedorn EJ, Motegi F, Kramer JM, Sherwood DR. (2011) Basement Membrane Sliding and Targeted Adhesion Remodels Tissue Boundaries During Uterine-vulval Attachment in Caenohrabditis elegans. Nat. Cell Biol 13: 641-651
Motegi F, Zonies S, Hao Y, Cuenca A, Griffin E, Seydoux G. (2011) Microtubules induce self-organization of polarized PAR domains in Caenohrabditis elegans zygotes. Nat. Cell Biol 13: 1361-1367 Kimura K and Kimura A. (2011) A novel mechanism of microtubule length-dependent force to pull centrosomes toward the cell center. Bioarchitecture. Mar;1(2): 74-79.
Kimura K and Kimura A. (2011) Intracellular organelles mediate cytoplasmic pulling force for centrosome centration in the Caenorhabditis elegans early embryo. Proc Natl Acad Sci U S A. 108(1): 137-42.
2010
Zonies S, Motegi F, Hao Y, Seydoux G. (2010) Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2. Development 137(10): 1669-77
Terasawa M, Toya M, Motegi F, Mana M, Nakamura K, Sugimoto A. (2010) Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Genes to Cells 15(11): 1145-57
Gallo CM, Wang JT, Motegi F, Seydoux G. (2010) Cytoplasmic Partitioning of P Granule Components Is Not Required to Specify the Germline in C. elegans. Science 330: 1685-1689
2008
Gassmann R, Essex A, Hu JS, Maddox PS, Motegi F, Sugimoto A, O’Rourke SM, Bowerman B, McLeod I, Yates JR, Oegema K, Cheeseman IM, Desai A. (2008) A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilich/ZW10. Genes and Development 22: 2385-2399
2007
Motegi F, Seydoux G. (2007) Revisiting the role of microtubules in C. elegans polarity. J. Cell Biol 179: 367-369
Kimura K, Tanaka N, Nakamura N, Takano S, Ohkuma S. (2007) Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in Caenorhabditis elegans. Journal of Biological Chemistry. 282(8): 5910-8.
2006
Motegi F, Veralde N, Piano F, Sugimoto A. (2006) Two phases of astral microtubule activity during cytokinesis in C. elegans embryos. Dev. Cell 10: 509-520
Motegi F, Sugimoto A. (2006) Sequential function of RHO-1 and CDC-42 establishes cell polarity in Caenohrabditis elegans embryos. Nat. Cell Biol 8: 978-985
Nishimura Y, Yonemura S. (2006) Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. J. Cell Sci. 119: 104-14.
2004
Motegi F, Mishra M, Balasubramanian MK, Mabuchi I. (2004) Myosin-II reorganization during mitosis is controlled temporally by its dephosphorylation and spatially by Mid1 in fission yeast. J. Cell Biol 165: 685-695
Yonemura S, Hirao-Minakuchi K, Nishimura Y. (2004) Rho localization in cells and tissues. Exp. Cell Res. 295(2): 300-314
2003
Nishimura Y, Mabuchi I. (2003) An IQGAP-like protein is involved in actin assembly together with Cdc42 in the sea urchin egg. Cell Motil. Cytoskeleton. 56(4): 207-218.
2002
Wong KCY, Naqvi NI, Motegi F, Mabuchi I, Balasubramanian MK. (2002) Importance of a myosin II-containing progenitor for actomyosin ring assembly in fission yeast. Curr. Biol 12: 724-729
2001
Toya M, Motegi F, Nakano K, Mabuchi I, Yamamoto M. (2001) Identification and functional analysis of the gene for type I myosin in fission yeast. Genes to Cells 6: 187-199
Noguchi T, Arai R, Motegi F, Nakano K, Mabuchi I. (2001) Contractile ring formation in Xenopus egg and fission yeast. Cell Struct. Funct 26: 545-554
Motegi F, Arai R, Mabuchi I. (2001) Identification of two type V myosins in fission yeast, one of which functions in polarized cell growth and moves rapidly in the cell. Mol. Biol. Cell 12: 1367-1380
2000
Le Goff X, Motegi F, Salimova F, Mabuchi I, Simanis V. (2000) The S. pombe rlc1 gene encodes a putative myosin regulatory light chain that binds the type II myosins myo3p and myo2p. J. Cell Sci 113: 4157-4163
Motegi F, Nakano K, Mabuchi I. (2000) Molecular mechanism of myosin-II assembly at the division site in Schizosaccharomyces pombe. J. Cell Sci 113: 1813-1825
1999
Suda M, Fukui M, Sogabe Y, Arai R, Motegi F., Miyakawa T, Mabuchi I, Hirata D. (1999) Overproduction of EF-1a causes aberrant cell morphology by affecting the control of growth polarity in fission yeast. Genes to Cells 4: 517-527
1998
Nishimura Y, Nakano K, Mabuchi I. (1998) Localization of Rho GTPase in sea urchin eggs. FEBS Lett. 441(1): 121-126
1997
Motegi F, Nakano K, Kitayama C, Yamamoto M, Mabuchi I. (1997) Identification of Myo3, a second type-II myosin heavy chain in the fission yeast Schizosaccharomyces pombe. FEBS Lett 420: 161-166