北海道大学 遺伝子病制御研究所 発生生理学分野 Institute for Genetic Medicine, Hokkaido University
A new study "Crosstalk between myosin II and formin functions in the regulation of force generation and actomyosin dynamics in stress fibers" by Yukako and her collaborators was published in Cells & Development.
- A review article "Fluid Flow Dynamics in Cellular Patterning" by Fumio and his collaborator, Kenji Kimura of Kwansei Gakuin Univ., was published in Seminars in Cell and Developmental Biology. Thanks Kenji for his contribution.
- Our work by Erica, Fumio, and our colleagues at RIKEN BDR (Fu-Lai Wen, Prabhat Shankar, and Tatsuo Shibata) was published in Cell Reports on 6th July. This paper is also highlighted by Hokkaido Univ and RIKEN.
- 西村有香子が、「第14回資生堂 女性研究者サイエンスグラント」に選出されました。資生堂が科学技術での活躍が期待される「指導的役割を目指す研究者」を支援することで、全ての人が輝く社会の実現を目指すプログラムです。 - Yukako was awarded for the 14th Shiseido Female Researcher Science Grant, which aims to promote future innovators engaged in education and research. Congratulation, Yukako!
Our group is interested in understanding the mechanical processes regulating: 1) The initiation of cell polarization and 2) The spatial patterning of cellular asymmetry. The simple model nematode system Caenorhabditis elegans provides a unique opportunity to explore such topics, as the embryos undergo de novo polarization with stereotypical spatio-temporal kinetics. We are also using cultured mammalian cells to investigate conserved cell polarity circuits. By using a multi-disciplinary approach, combining genetics, biochemistry, and modern imaging technology, our group aims to understand: 1. The nature of the cue(s) that initiate cell polarization 2. The mechanics of spatial patterning of cellular asymmetry 3. The role of polarity kinases in the germ-soma dichotomy 4. The mechanisms underlying tissue homeostasis
In order to delve into the mysteries in living systems, we develop new types of confocal fluorescence microscopies and image behaviours of molecules, cells, and tissues in living animals. See the beauty in microtubules, actin filaments, and regulators of cellular asymmetry in live cells.
We acknowledge the following foundations and organization, which support our research program in Singapore and Japan.